The cell membrane is not only a physical barrier, but also a functional organelle that
regulates the communication between a cell and its environment. The ability to functionalize …

Cell signaling is initiated by characteristic protein patterns in the plasma membrane, but
tools to decipher their molecular organization and activation are hitherto lacking. Among the …

The immunological response of mast cells is controlled by the multivalent binding of
antigens to immunoglobulin E (IgE) antibodies bound to the high-affinity receptor FcεRI on …

The nanoscale arrangement of ligands can have a major effect on the activation of
membrane receptor proteins and thus cellular communication mechanisms. Here we report …

Proteins execute numerous cell functions in concert with one another in protein–protein
interactions (PPI). While essential in each cell, such interactions are not identical from cell to …

Analysis of protein–protein interactions in living cells by protein micropatterning is currently
limited to the spatial arrangement of transmembrane proteins and their corresponding …

News from an old acquaintance: The streptavidin (STV)‐biotin binding system is frequently
used for the decoration of DNA origami nanostructures (DON) to study biological systems …

The incretin hormones: glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) are important regulators of many aspects of metabolism including …

At the plasma membrane of mammalian cells, major histocompatibility complex class I
molecules (MHC-I) present antigenic peptides to cytotoxic T cells. Following the loss of the …

Traditionally, the use of DNA origami nanostructures (DONs) to study early cell signaling
processes has been conducted using standard laboratory equipment with DONs typically …