With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

Significance: An estimated 700 million people globally suffer from chronic kidney disease
(CKD). In addition to increasing cardiovascular disease risk, CKD is a catabolic disease that …

Age‐associated loss of muscle mass and function (sarcopenia) has a profound effect on the
quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice …

The loss of muscle mass and function with age, termed sarcopenia, is an inevitable process,
which has a significant impact on quality of life. During ageing we observe a progressive …

Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive
skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy …

Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function,
and significantly reduced load on skeletal muscle, resulting in atrophy. Factors such as …

Research over almost 40 years has established that reactive oxygen species are generated
at different sites in skeletal muscle and that the generation of these species is increased by …

Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic
health. Reactive oxygen species (ROS) have emerged as intracellular messengers …

The loss of muscle mass and force characterizes muscle atrophy in several different
conditions, which share the expression of atrogenes and the activation of their …

Insufficient stress response and elevated oxidative stress can contribute to skeletal muscle
atrophy during mechanical unloading (eg, spaceflight and bedrest). Perturbations in heat …