Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

Microglia are resident macrophages of the central nervous system and significantly
contribute to overall brain function by participating in phagocytosis during development …

Microglia, the brain's resident macrophages, are incredibly plastic and dynamic cells. In this
chapter, we aim to describe and classify the many morphological changes they can display …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed
different phenotypes that are inherently associated with disease conditions. A common …

Background Abnormal lipid accumulation has been recognized as a key element of immune
dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases …

Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive
functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is …

Huntington's disease (HD) is a neurodegenerative disorder that manifests with movement
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …

Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …