The neuroprotective effects of oxygen therapy in Alzheimer's disease: a narrative review

C Yang, Q Yang, Y Xiang, XR Zeng… - Neural regeneration …, 2023 - journals.lww.com
Alzheimer's disease (AD) is a degenerative neurological disease that primarily affects the
elderly. Drug therapy is the main strategy for AD treatment, but current treatments suffer from …

Hypoxia-induced signaling activation in neurodegenerative diseases: targets for new therapeutic strategies

NK Jha, SK Jha, R Sharma, D Kumar… - Journal of …, 2018 - content.iospress.com
For the maintenance of cellular homeostasis and energy metabolism, an uninterrupted
supply of oxygen (O 2) is routinely required in the brain. However, under the impaired level …

[HTML][HTML] Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer's disease mouse model and in elderly patients

R Shapira, A Gdalyahu, I Gottfried, E Sasson… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Vascular dysfunction is entwined with aging and in the pathogenesis of Alzheimer's disease
(AD) and contributes to reduced cerebral blood flow (CBF) and consequently, hypoxia …

Bridging the gap between gut microbiota and Alzheimer's disease: a metaproteomic approach for biomarker discovery in transgenic mice

E Ayan, H DeMirci, MA Serdar, F Palermo… - International Journal of …, 2023 - mdpi.com
Alzheimer's Disease (AD) is a progressively debilitating form of dementia that affects millions
of individuals worldwide. Although a vast amount of research has investigated the complex …

Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation

R Shapira, B Solomon, S Efrati, D Frenkel… - Neurobiology of …, 2018 - Elsevier
There is a real need for new interventions for Alzheimer's disease (AD). Hyperbaric oxygen
therapy (HBOT), the medical administration of 100% oxygen at conditions greater than 1 …

Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats

L Sun, L Min, H Zhou, M Li, F Shao, W Wang - Behavioural Brain Research, 2017 - Elsevier
Social isolation is regarded as a cause of schizophrenia spectrum disorders. Animal models
of schizophrenia are constructed by repeated early environment deprivation as an important …

Proteomics evidence of the role of TDMQ20 in the cholinergic system and synaptic transmission in a mouse model of Alzheimer's disease

F Sun, J Zhao, H Zhang, Q Shi, Y Liu… - ACS Chemical …, 2022 - ACS Publications
The interaction between copper ions and amyloid peptide Aβ has been reported to be
involved in Alzheimer's disease (AD) pathology. Based on copper coordination …

Identification of candidate biomarkers for the prediction of gestational diabetes mellitus in the early stages of pregnancy using iTRAQ quantitative proteomics

D Zhao, L Shen, Y Wei, J Xie, S Chen… - PROTEOMICS …, 2017 - Wiley Online Library
Purpose Gestational diabetes mellitus (GDM) is one of the most common medical problems
of pregnancy. This study is designed to identify serum biomarkers, which can predict the …

Proteomic profiling of cerebrum mitochondria, myelin sheath, and synaptosome revealed mitochondrial damage and synaptic impairments in association with 3× Tg …

L Shen, A Yang, X Chen, S Xiao, X Liu, J Lin… - Cellular and Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common age-associated dementia with complex
pathological hallmarks. Mitochondrion, synaptosome, and myelin sheath appear to be …

Effect of sodium selenate on hippocampal proteome of 3× Tg-AD mice—exploring the antioxidant dogma of selenium against Alzheimer's disease

J Iqbal, K Zhang, N Jin, Y Zhao, Q Liu… - ACS Chemical …, 2018 - ACS Publications
Selenium (Se), an antioxidant trace element, is an important nutrient for maintaining brain
functions and is reported to be involved in Alzheimer's disease (AD) pathologies. The …