Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Innate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have
important functions in protecting epithelial barriers against infections and in maintaining …

Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and
collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe …

Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of …

The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays
essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs …

Congenital hypogonadotropic hypogonadism (CHH) and its anosmia-associated form
(Kallmann syndrome [KS]) are genetically heterogeneous. Among the> 15 genes implicated …