Nasopharyngeal carcinoma—review of the molecular mechanisms of tumorigenesis

J Chou, YC Lin, J Kim, L You, Z Xu… - Head & Neck …, 2008 - Wiley Online Library
Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the
world but common in certain geographic areas, such as southern Asia. While environmental …

In vitro skin irritation: facts and future. State of the art review of mechanisms and models

T Welss, DA Basketter, KR Schröder - Toxicology in vitro, 2004 - Elsevier
The skin is the main target tissue for exogenous noxes, protecting us from harmful
environmental hazards, UV-irradiation and endogenous water loss. It is composed of three …

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

B Do Van, F Gouel, A Jonneaux, K Timmerman… - Neurobiology of …, 2016 - Elsevier
Parkinson's disease (PD) is a complex illness characterized by progressive dopaminergic
neuronal loss. Several mechanisms associated with the iron-induced death of dopaminergic …

Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory

A Morozov, IA Muzzio, R Bourtchouladze, N Van-Strien… - Neuron, 2003 - cell.com
Learning-induced synaptic plasticity commonly involves the interaction between cAMP and
p42/44MAPK. To investigate the role of Rap1 as a potential signaling molecule coupling …

Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation

Z Liu, W Zhang, JB Phillips, R Arora, S McClellan, J Li… - Oncogene, 2019 - nature.com
B7-H3 is a tumor-promoting glycoprotein that is expressed at low levels in most normal
tissues, but is overexpressed in various human cancers which is associated with disease …

Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

B Raghavan, SF Martin, PR Esser, M Goebeler… - EMBO …, 2012 - embopress.org
Development of contact allergy requires cooperation of adaptive and innate immunity. Ni2+
stimulates innate immunity via TLR4/MD2, the bacterial LPS receptor. This likely involves …

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

AW Lin, SW Lowe - … of the National Academy of Sciences, 2001 - National Acad Sciences
Chemically induced skin carcinomas in mice are a paradigm for epithelial neoplasia, where
oncogenic ras mutations precede p53 and INK4a/ARF mutations during the progression …

Elevated serum levels of calcium‐binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis

S Benoit, A Toksoy, M Ahlmann… - British Journal of …, 2006 - academic.oup.com
Background The expression of calcium‐binding S100 molecules organized within the
epidermal differentiation complex on chromosome 1q21 is disturbed in hyperproliferative …

Nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers

W Tulalamba, T Janvilisri - International journal of cell biology, 2012 - Wiley Online Library
Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic
and geographic distribution. Etiology of NPC is considered to be related with a complex …

Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation

Z Fonseca, C Díaz-Godínez, N Mora… - Frontiers in cellular …, 2018 - frontiersin.org
Amoebiasis, the disease caused by Entamoeba histolytica is the third leading cause of
human deaths among parasite infections. E. histolytica was reported associated with around …