Making a good egg: human oocyte health, aging, and in vitro development

EE Telfer, J Grosbois, YL Odey… - Physiological …, 2023 - journals.physiology.org
Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease

M McCarthy, AP Raval - Journal of neuroinflammation, 2020 - Springer
The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …

Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary

JK Bhardwaj, A Paliwal, P Saraf… - Journal of cellular …, 2022 - Wiley Online Library
The reproductive life span of the organism mainly depends on follicular development that
maintains the primordial follicle pool in the cohort of follicles within the ovary. The total count …

Endocrine disrupting chemicals impact on ovarian aging: Evidence from epidemiological and experimental evidence

T Ding, W Yan, T Zhou, W Shen, T Wang, M Li… - Environmental …, 2022 - Elsevier
Endocrine-disrupting chemicals (EDCs) are ubiquitous in daily life, but their harmful effects
on the human body have not been fully explored. Recent studies have shown that EDCs …

Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats

MA Brieño-Enríquez, M Faykoo-Martinez… - Nature …, 2023 - nature.com
In the long-lived naked mole-rat (NMR), the entire process of oogenesis occurs postnatally.
Germ cell numbers increase significantly in NMRs between postnatal days 5 (P5) and P8 …

The effects of endocrine‐disrupting chemicals on ovarian‐and ovulation‐related fertility outcomes

KL Land, FG Miller, AC Fugate… - Molecular …, 2022 - Wiley Online Library
Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a
public health concern given the ability of EDCs to target the ovary. However, there is a large …

[HTML][HTML] Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly

JJ Wang, Y Tian, MH Li, YQ Feng, L Kong, FL Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Accumulated evidence indicates that environmental plasticizers are a threat to
human and animal fertility. Di (2-ethylhexyl) phthalate (DEHP), a plasticizer to which humans …

Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary

DD Meling, M Kathy, AS Arango, A Gonsioroski… - Reproductive …, 2022 - Elsevier
Widespread use of phthalates as solvents and plasticizers leads to everyday human
exposure. The mechanisms by which phthalate metabolites act as ovarian toxicants are not …

The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice

DD Meling, GR Warner, JR Szumski, L Gao… - Toxicology and applied …, 2020 - Elsevier
Phthalates are used as solvents and plasticizers in a wide variety of consumer products.
Most people are exposed to phthalates as parent compounds through ingestion, inhalation …

Triclocarban exposure affects mouse oocyte in vitro maturation through inducing mitochondrial dysfunction and oxidative stress

ZM Ding, MJ Ahmad, F Meng, F Chen, YS Wang… - Environmental …, 2020 - Elsevier
Abstract Triclocarban (TCC), a broad-spectrum lipophilic antibacterial agent, is the main
ingredient of personal and health care products. Nonetheless, its ubiquitous presence in the …