Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Integration is vital to retroviral replication and influences the establishment of the latent HIV
reservoir. HIV-1 integration favors active genes, which is in part determined by the …

New genetic tools are needed to understand the functional interactions between HIV and
human host factors in primary cells. We recently developed a method to edit the genome of …

Chromosomal integration enables human immunodeficiency virus (HIV) to establish a
permanent reservoir that can be therapeutically suppressed but not eradicated. Participation …

Integration of retroviral DNA into host cell DNA is a defining feature of retroviral replication.
HIV integration is known to be favored in active transcription units, which promotes efficient …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Abstract Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA
copy of their genome after entry into the host cell. Integration of this DNA into the host cell's …

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration
complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 …

The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in
infected patients under HAART since interruption of the treatment inevitably leads to a …