Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

Highlights•The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic
inflammation at mucosal surfaces.•The precise function of these cytokines during human …

Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …

Highlights•Primarily located in the nucleus, IL-33 is an alarmin and transcription factor.•IL-33
and ST2 polymorphisms are implicated in a wide range of diseases.•IL-33 drives pro …

Background Respiratory viral infections are one of the leading causes of need for
emergency care and hospitalizations in asthmatic individuals, and airway-secreted …

ABSTRACT Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It modulates
immune responses and biological functions through binding to its membrane receptor …

We reported previously that priming of the respiratory tract with immunobiotic Lactobacillus
prior to virus challenge protects mice against subsequent lethal infection with pneumonia …

Subclinical primary Pneumocystis infection is the most common pulmonary infection in early
infancy, making it important to determine whether it damages the lung. Pneumocystis peaks …

Human mature IL-33 is a member of the IL-1 family and a potent regulator of immunity
through its pro-T helper cell 2 activity. Its precursor form, full-length interleukin-33 (FLIL33) …

Viral pneumonias remain global health threats, as exemplified in the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, requiring novel treatment …