mRNA vaccines have brought about a great revolution in the vaccine fields owing to their
simplicity and adaptability in antigen design, potential to induce both humoral and cell …

H7N9 influenza viruses were first isolated in 2013 and continue to cause human infections.
H7N9 infections represent an ongoing public health threat that has resulted in 1344 cases …

Background We evaluated safety and immunogenicity of the first mRNA vaccines against
potentially pandemic avian H10N8 and H7N9 influenza viruses. Methods Two randomized …

Emerging and well-known viral diseases remain one the most important global public health
threats. A better understanding of their pathogenesis and mechanisms of transmission …

Zoonotic viruses that emerge from wildlife and domesticated animals pose a serious threat
to human and animal health. In many instances, mouse models have improved our …

In March 2013 the first cases of human avian influenza A (H7N9) were reported to the World
Health Organization. Since that time, over 650 cases have been reported. Infections are …

In February 2013, zoonotic transmission of a novel influenza A virus of the H7N9 subtype
was reported in China. Although at present no sustained human-to-human transmission has …

CD 4 T cells convey a number of discrete functions to protective immunity to influenza, a
complexity that distinguishes this arm of adaptive immunity from B cells and CD 8 T cells …

The recent emergence of severe human illness caused by avian-origin influenza A (H7N9)
viruses in China has precipitated a global effort to rapidly develop and test vaccine …

Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly
strain-specific and limited heterosubtypic responses. To better understand how vaccine …