Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application
Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …
Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery
H Wang, L Qin, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2022 - Elsevier
With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …
Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain
Genome editing using CRISPR/Cas9 has attracted considerable attention for the treatment
of genetic disorders and viral infections. Co-delivery of Cas9 mRNA and single guide (sg) …
of genetic disorders and viral infections. Co-delivery of Cas9 mRNA and single guide (sg) …
Polymer gene delivery: overcoming the obstacles
Highlights•Minor modifications to polymer structure determine transfection
properties.•Efficient gene delivery requires timely release of DNA.•Serum stability is …
properties.•Efficient gene delivery requires timely release of DNA.•Serum stability is …
Polyplex designs for improving the stability and safety of RNA therapeutics
Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety
S Uchida, H Kinoh, T Ishii, A Matsui, TA Tockary… - Biomaterials, 2016 - Elsevier
Systemic delivery of messenger RNA (mRNA) is technically challenging because mRNA is
highly susceptible to enzymatic degradation in the blood circulation. In this study, we used a …
highly susceptible to enzymatic degradation in the blood circulation. In this study, we used a …
Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 …
P Ruenraroengsak, TD Tetley - Particle and fibre toxicology, 2015 - Springer
Background Engineered nanoparticles (NP) are being developed for inhaled drug delivery.
This route is non-invasive and the major target; alveolar epithelium provides a large surface …
This route is non-invasive and the major target; alveolar epithelium provides a large surface …
Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA
Nonviral delivery of plasmid (p) DNA or messenger (m) RNA is a safe and promising
therapeutic option to continuously supply therapeutic proteins into diseased tissues. In most …
therapeutic option to continuously supply therapeutic proteins into diseased tissues. In most …
Pulmonary siRNA delivery for lung disease: review of recent progress and challenges
Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …
new therapies. Approval of the first siRNA treatments in humans has opened the door for …
Polycations and their biomedical applications
Polycations are useful delivery vehicles for nucleic acids and proteins. Physicochemical
properties, safety, and cost are important design parameters for polycation-enabled …
properties, safety, and cost are important design parameters for polycation-enabled …