Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of
UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes …

Nucleotide excision repair removes UV-induced DNA damage through two distinct sub-
pathways, global repair and transcription-coupled repair (TCR). Numerous studies have …

After reconstitution of nucleotide excision repair (excision repair) with XPA, RPA, XPC, TFIIH,
XPF-ERCC1 and XPG, it was concluded that these six factors are the minimal essential …

There is currently no established intervention for Cockayne syndrome, a disease
characterized by progressive early onset neurodegeneration with features of premature …

Bulky DNA adducts such as those induced by ultraviolet light are removed from the
genomes of multicellular organisms by nucleotide excision repair, which occurs through two …