Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Abstract CircaDB (http://circadb. org) is a new database of circadian transcriptional profiles
from time course expression experiments from mice and humans. Each transcript's …

Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erbα, a
transcription factor (TF) that functions both as a core repressive component of the cell …

RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …

The circadian clock controls several aspects of mammalian physiology and orchestrates the
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …

Defects in circadian rhythm influence physiology and behavior with implications for the
treatment of sleep disorders, metabolic disease, and cancer. Although core regulatory …

In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …

RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH 17)
cell development. However, the cell-intrinsic mechanisms that negatively regulate TH 17 cell …