[HTML][HTML] Therapeutic intervention for wear debris-induced aseptic implant loosening

K Ren, A Dusad, Y Zhang, D Wang - Acta Pharmaceutica Sinica B, 2013 - Elsevier
Wear debris-induced aseptic loosening is an inflammatory bone disorder, which
compromises the long-term success of total joint replacement. Despite the extensive …

Biological effects of wear particles generated in total joint replacements: trends and future prospects

S Suñer, JL Tipper, N Emami - Tribology-Materials, Surfaces …, 2012 - journals.sagepub.com
Joint replacements have considerably improved the quality of life of patients with joints
damaged by disease or trauma. However, problems associated with wear particles …

Cross-linked compared with historical polyethylene in THA: an 8-year clinical study

CH Geerdink, B Grimm, W Vencken… - Clinical Orthopaedics …, 2009 - journals.lww.com
Wear particle-induced osteolysis is a major cause of aseptic loosening in THA. Increasing
wear resistance of polyethylene (PE) occurs by increasing the cross-link density and early …

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

K Ren, A Dusad, F Yuan, H Yuan, PE Purdue… - Journal of controlled …, 2014 - Elsevier
Aseptic implant loosening related to implant wear particle-induced inflammation is the most
common cause of failure after joint replacement. Modulation of the inflammatory reaction to …

10-year follow-up wear analysis of first-generation highly crosslinked polyethylene in primary total hip arthroplasty

N Snir, ID Kaye, CS Klifto, MJ Hamula… - The Journal of …, 2014 - Elsevier
Our goal was to report a 10-year follow up of linear penetration rates for HCLPE, and to
determine whether a difference exists between penetrations measured on pelvis or hip …

An in vivo murine model of continuous intramedullary infusion of polyethylene particles

T Ma, Z Huang, PG Ren, R McCally, D Lindsey… - Biomaterials, 2008 - Elsevier
Wear debris affects both initial osseointegration and subsequent bone remodeling of total
joint replacements (TJRs). To study the complex cascade associated with the continuous …

Characteristics of VE/HXLPE wear particle morphology: A comparative analysis with UHMWPE in an in vitro artificial tibial insert simulation test

Z Hua, M Hu, B Sheng, X Huang, J Zhu, Z Jin - Wear, 2024 - Elsevier
Particle generation from artificial knee prostheses is a leading cause of artificial joint failures.
Vitamin E stabilized highly cross-linked polyethylene (VE/HXLPE) is known for its …

Delayed-onset edematous foreign body granulomas 40 years after augmentation rhinoplasty by silicone implant combined with liquid silicone injection

HC Hu, HW Fang, YH Chiu - Aesthetic Plastic Surgery, 2017 - Springer
Despite the widespread application of augmentation rhinoplasty in Asia, reports on the
interaction between alloplastic implants and injectable filler are scarce. This paper reports …

In vivo murine model of continuous intramedullary infusion of particles—A preliminary study

T Ma, SG Ortiz, Z Huang, P Ren… - … Research Part B …, 2009 - Wiley Online Library
Continued production of wear debris affects both initial osseointegration and subsequent
bone remodeling of total joint replacements (TJRs). However, continuous delivery of …

Cobalt, titanium and PMMA bone cement debris influence on mouse osteoblast cell elasticity, spring constant and calcium production activity

EC Preedy, S Perni, P Prokopovich - RSC advances, 2015 - pubs.rsc.org
Periprosthetic osteolysis and implant loosening are the outcomes of wear debris generation
in total joint replacements. Wear debris formed from the implanted materials consisting of …