[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

JPJ Merlin, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …

Natural guardians: Natural compounds as radioprotectors in cancer therapy

A Stasiłowicz-Krzemień, A Gościniak… - International Journal of …, 2024 - mdpi.com
Cancer remains a significant global health challenge, with millions of deaths attributed to it
annually. Radiotherapy, a cornerstone in cancer treatment, aims to destroy cancer cells …

Role of antioxidant vitamins and other micronutrients on regulations of specific genes and signaling pathways in the prevention and treatment of cancer

OF Fagbohun, CR Gillies, KPJ Murphy… - International Journal of …, 2023 - mdpi.com
Cancer is an escalating global issue, with 19.3 million new cases and 9.9 million deaths in
2020. Therefore, effective approaches to prevent cancer are urgently required. Diet plays a …

Genistein and procyanidin B2 reduce carcinogen-induced reactive oxygen species and DNA damage through the activation of Nrf2/ARE cell signaling in Bronchial …

TL Suraweera, JPJ Merlin, G Dellaire, Z Xu… - International Journal of …, 2023 - mdpi.com
Cancer is one of the leading causes of death worldwide. Chemotherapy and radiation
therapy are currently providing the basis for cancer therapies, although both are associated …

[HTML][HTML] Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

JPJ Merlin, A Crous, H Abrahamse - International journal of molecular …, 2024 - mdpi.com
Cancer treatment continues to be a substantial problem due to tumor complexities and
persistence, demanding novel therapeutic techniques. This review investigates the …

Nano‐phototherapy: Favorable prospects for cancer treatment

JPJ Merlin, A Crous… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Nanotechnology‐based phototherapies have drawn interest in the fight against cancer
because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting …

Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

SS Rajan, R Chandran… - International Journal of …, 2024 - Taylor & Francis
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer
therapeutic option, especially when enhanced by nanoconjugation. This review investigates …

Proapoptotic Peptide-Templated Au Nanoclusters Selectively Enhance Radiosensitivity of Cancer Cells

Y Shi, Z Liang, M Jiang, J Qin, X Fei, Y Chen… - Chemistry of …, 2024 - ACS Publications
Radiotherapy is an important treatment strategy in clinical oncology, but patients still take the
risk of severe side effects when receiving radiation. It is urgent to develop safe and efficient …

Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

SS Rajan, R Chandran… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Cancer presents a formidable challenge, necessitating innovative therapies that maximize
effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a …

Ultra-processed food consumption and risk of chronic respiratory diseases mortality among adults: evidence from a prospective cohort study

TC Mekonnen, YA Melaku, Z Shi, TK Gill - European Journal of Nutrition, 2024 - Springer
Purpose The purpose of the study was to determine the relationships between ultra-
processed food (UPF) consumption and risk of mortality due to chronic respiratory diseases …