The lasting threat of viral pandemics necessitates the development of tailorable first-
response antivirals with specific but adaptive architectures for treatment of novel viral …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for causing
the current coronavirus 2019 (COVID-19) pandemic, uses its spike (S1) protein for host cell …

Existing methods for interpreting protein variation focus on annotating mutation
pathogenicity rather than detailed interpretation of variant deleteriousness and frequently …

Several methods have been developed to predict effects of amino acid substitutions on
protein stability. Benchmark datasets are essential for method training and testing and have …

Rapidly predicting enzyme properties for catalyzing specific substrates is essential for
identifying potential enzymes for industrial transformations. The demand for sustainable …

Nattokinase (NK) is an enzyme that has been recognized as a new potential thrombolytic
drug due to its strong thrombolytic activity. However, it is difficult to maintain the enzyme …

Mutants remain a powerful means for dissecting gene function in model organisms such as
Caenorhabditis elegans. Massively parallel sequencing has simplified the detection of …

Fructooligosaccharides (FOSs) are well-known prebiotics that are widely used in the food,
beverage and pharmaceutical industries. Inulosucrase (EC 2.4. 1.9) can potentially be used …

The adult Caenorhabditis elegans hermaphrodite gonad consists of two mirror-symmetric U-
shaped arms, with germline nuclei located peripherally in the distal regions of each arm. The …

Here we describe the development and characterization of the photo-N-degron, a peptide
tag that can be used in optogenetic studies of protein function in vivo. The photo-N-degron …