The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

It is unclear how disease mutations impact intrinsically disordered protein regions (IDRs),
which lack a stable folded structure. These mutations, while prevalent in disease, are …

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle
network of protein interactions. The tumor suppressor protein p53 triggers transcription …

The solid tumour microenvironment includes nerve fibres that arise from the peripheral
nervous system,. Recent work indicates that newly formed adrenergic nerve fibres promote …

The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

TP53 is the most frequently mutated gene in cancer, yet these mutations remain
therapeutically non-actionable. Major challenges in drugging p53 mutations include …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …

Over the past decade, cold atmospheric plasma (CAP), a near room temperature ionized
gas has shown its promising application in cancer therapy. Two CAP devices, namely …