Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB …

SS Josiah, CD Famusiwa, OO Crown, AO Lawal… - Neurotoxicology, 2022 - Elsevier
The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …

Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model

KS Mughal, M Ikram, Z Uddin, A Rashid… - Biochemical and …, 2024 - Elsevier
Syringic acid (SA), a naturally occurring phenolic substance present in many edible plants
and fruits, has been shown to have potential in immunoenhancement applications. In this …

Dihydroquercetin improves rotenone‐induced parkinsonism by regulating NF‐κB‐mediated inflammation pathway in rats

AC Akinmoladun, CD Famusiwa… - … of Biochemical and …, 2022 - Wiley Online Library
This study examined the effect of dihydroquercetin (DHQ), also knofigurewn as taxifolin, on
rotenone‐induced Parkinsonism in rats. Male Wistar rats were administered 1.5 mg/kg …

Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients

AS Ramalho, MA Lewandowska, CM Farinha… - Cellular Physiology and …, 2009 - karger.com
Abstract Background/Aims: Mutations in the CFTR gene cause Cystic Fibrosis (CF) the most
common life-threatening autosomal recessive disease affecting Caucasians. We identified a …

Bacterial transfer of large functional genomic DNA into human cells

A Laner, S Goussard, AS Ramalho, T Schwarz… - Gene therapy, 2005 - nature.com
Efficient transfer of chromosome-based vectors into mammalian cells is difficult, mostly due
to their large size. Using a genetically engineered invasive Escherichia coli vector, alpha …

Identification of an optimal method for extracting RNA from human skin biopsy, using domestic pig as a model system

E Reimann, K Abram, S Kõks, K Kingo, A Fazeli - Scientific reports, 2019 - nature.com
To evaluate skin tissue gene expression patterns correctly, extracting sufficient quantities of
good quality RNA is essential. However, RNA extraction from skin tissue is challenging, as …

[HTML][HTML] Comparative ex vivo, in vitro and in silico analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations

AS Ramalho, LA Clarke, M Sousa, V Felicio… - Journal of Cystic …, 2016 - Elsevier
Abstract The Cystic Fibrosis p. Ile1234Val missense mutation actually creates a new dual
splicing site possibly used either as a new acceptor or donor. Here, we aimed to test the …

[HTML][HTML] Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy

H Sun, X Wang, Y Li, Y Shen, L Zhang, Y Xu, J Liu… - Pharmaceutics, 2024 - mdpi.com
Hyperuricemia, ie, increased plasma uric acid concentration, is a common problem in
clinical practice, leading to gout or nephrolithiasis, and is associated with other disorders …

The CFTR gene variants in Japanese children with idiopathic pancreatitis

M Iso, M Suzuki, K Yanagi, K Minowa… - Human Genome …, 2019 - nature.com
The cystic fibrosis transmembrane conductance regulator (CFTR) gene has been reported
as one of the pancreatitis susceptibility genes. Although many variants of CFTR have been …

A practical approach for exploration and modeling of the design space of a bacterial vaccine cultivation process

M Streefland, PFG Van Herpen… - Biotechnology and …, 2009 - Wiley Online Library
A licensed pharmaceutical process is required to be executed within the validated ranges
throughout the lifetime of product manufacturing. Changes to the process, especially for …