Gene duplications and their subsequent divergence play an important part in the evolution
of novel gene functions. Several models for the emergence, maintenance and evolution of …

Simple repetitive DNA sequences are a widespread and abundant feature of genomic DNA.
The following several features characterize such sequences:(1) they typically consist of a …

We have systematically made a set of precisely defined, single‐gene deletions of all
nonessential genes in Escherichia coli K‐12. Open‐reading frame coding regions were …

2012 still-prevalent view that every bit of an organism's DNA has a specific function crafted
by selection. Thus, both papers promoted Dawkins' concept of “selfish DNA”—the notion that …

Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

Abstract Changes in gene copy number are among the most frequent mutational events in
all genomes and were among the mutations for which a physical basis was first known. Yet …

Background Gene duplications have a major role in the evolution of new biological
functions. Theoretical studies often assume that a duplication per se is selectively neutral …

The traditional view of the stationary phase of the bacterial life cycle, obtained using
standard laboratory culture practices, although useful, might not always provide us with the …

Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic
individuality, a biological phenomenon that is considered to bolster the fitness of …