Cancer cells must maintain metabolic homeostasis under a wide range of conditions and
meet their own energy needs in order to survive and reproduce. In addition to glycolysis …

Monotopic membrane proteins, classified by topology, are proteins that embed into a single
face of the membrane. These proteins are generally underrepresented in the Protein Data …

To understand the contribution of adipose tissue fatty acid oxidation to whole-body
metabolism, we generated mice with an adipose-specific knockout of carnitine …

Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and
cause drastic losses in crops and livestock. New anthelmintic drugs are urgently needed as …

The metabolism of fatty acids, including their absorption, storage, mobilization, synthesis,
and catabolism, has been the origin and target of innumerable drugs and pharmacological …

Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis
of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial …

Obesity is often accompanied by metabolic disorder and insulin resistance, resulting in type
2 diabetes. Based on previous findings, FYGL, a natural hyperbranched proteoglycan …

The control of fatty acid translocation across the mitochondrial membrane is mediated by the
carnitine palmitoyltransferase (CPT) system. Modulation of its functionality has simultaneous …

Saturated fatty acids (SFAs)(the" bad" fat), especially palmitate (PA), in the human diet are
blamed for potential health risks such as obesity and cancer because of SFA-induced …

Defects in lipid metabolism can affect either the mitochondrial transport and oxidation of
exogenous fatty acid or the catabolism of endogenous triglycerides. These disorders impair …