Tumours are often composed of a multitude of malignant clones that are genomically
unique, and only a few of them may have the ability to escape cancer therapy and grow as …

The field of cancer research is increasingly recognizing the complex interplay between
biomechanics and tumor epigenetics. Biomechanics plays a significant role in the …

Clonal growth and competition underlie processes of key relevance in etiology, progression
and therapy response across all cancers. Here, we demonstrate a novel experimental …

Cancers are a leading cause of death around the world, accounting for nearly 10 million
deaths yearly. Scientists across the globe are intensifying more and more of their efforts to …

类器官是在体外通过细胞自组织生长而形成的三维结构， 它具有许多与相应在体器官相类似的
结构和功能。 类器官培养技术发展迅速， 起源细胞类型丰富， 但是现有技术培养的类器官和 …

Lineage tracing methods have extensively advanced our understanding of physiological cell
behaviour in vivo and in situ and have vastly contributed to decipher the phylogeny and …

Adoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has
provided unparalleled opportunities to compare cell growth factor and signaling …

类器官是在体外通过细胞自组织生长而形成的三维结构, 它具有许多与相应在体器官相类似的
结构和功能. 类器官培养技术发展迅速, 起源细胞类型丰富, 但是现有技术培养的类器官和真正的 …

Breast tumors exhibit significant cellular heterogeneity that influences patient prognosis and
treatment outcomes. Heterogeneous cancer and microenvironmental populations defined by …