Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on
their brain health and behavior. During the past three decades, obesity has rapidly …

Exposure to environmental enrichment can beneficially influence the behavior and enhance
synaptic plasticity. The aim of the present study was to investigate the mediated effects of …

Mitochondria and mitochondria‐mediated signalling pathways are known to control synaptic
signalling, as well as long‐lasting changes in neuronal structure and function. Mitochondrial …

Cumulative evidence shows that modifications in lifestyle factors constitute an effective
strategy to modulate molecular events related to neurodegenerative diseases, confirming …

Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding
exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that …

Background. Fluoxetine (FLU) is the first‐line and widely used medication for depression;
however, FLU treatment is almost ineffective in 30%‐40% of patients with depression. In …

Highlights•Perinatal depression is a common complication of pregnancy.•It is widely
overlooked partly due to lack of biomarkers.•BDNF has psychostablizing effects with …