Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that
allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and …

In a complex system of interrelated reactions, the heart converts chemical energy to
mechanical energy. Energy transfer is achieved through coordinated activation of enzymes …

Rationale: Altered cardiac energetics is known to play an important role in the progression
toward heart failure. A noninvasive method for imaging metabolic markers that could be …

This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]
pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for …

The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …

Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …

Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …

Hyperpolarized magnetic resonance allows for noninvasive measurements of biochemical
reactions in vivo. Although this technique provides a unique tool for assaying enzymatic …

Aims Impaired energy metabolism has been implicated in the pathogenesis of heart failure.
Hyperpolarized 13C magnetic resonance (MR), in which 13C‐labelled metabolites are …