A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

Epigenetic dysregulation is a common feature of most cancers, often occurring directly
through alteration of epigenetic machinery. Over the last several years, a new generation of …

We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse
intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of> …

In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Grade II and III gliomas are generally slowly progressing brain cancers, many of which
eventually transform into more aggressive tumors. Despite recent findings of frequent …

Scant understanding of the glioblastoma microenvironment and molecular bases hampers
development of efficient treatment strategies. Analyses of gene signatures of human gliomas …

Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival
rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic …

The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …