DNA‐based nanoarchitectures as eminent vehicles for smart drug delivery systems

M Komiyama, N Shigi, K Ariga - Advanced Functional Materials, 2022 - Wiley Online Library
In order to cure diseases efficiently with minimal side effects in sophisticated medicine,
eminent drugs must be selectively delivered to diseased parts and allow to work only there …

Recent advances in boosting EGFR tyrosine kinase inhibitors-based cancer therapy

Q Pan, Y Lu, L Xie, D Wu, R Liu, W Gao… - Molecular …, 2023 - ACS Publications
Epidermal growth factor receptor (EGFR) plays a key role in signal transduction pathways
associated with cell proliferation, growth, and survival. Its overexpression and aberrant …

Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells

J Han, Y Cui, Z Gu, D Yang - Biomaterials, 2021 - Elsevier
Developing nanocarrier systems with sufficient drug loading ability and efficient drug release
behavior in cells is a powerful strategy to maximize therapeutic efficacies and minimize side …

Targeted co-delivery of curcumin and erlotinib by MoS2 nanosheets for the combination of synergetic chemotherapy and photothermal therapy of lung cancer

Z Chen, X Wei, Y Zheng, Z Zhang, W Gu, W Liao… - Journal of …, 2023 - Springer
Abstract Background Curcumin (Cur), a bioactive component of Chinese traditional
medicine, has demonstrated inhibitory properties against cancer cell proliferation while …

DNA-Based Nonviral Gene Therapy─ Challenging but Promising

X Guan, Y Pei, J Song - Molecular Pharmaceutics, 2024 - ACS Publications
Over the past decades, significant progress has been made in utilizing nucleic acids,
including DNA and RNA molecules, for therapeutic purposes. For DNA molecules, although …

Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics

S Alexander, MG Moghadam, M Rothenbroker… - Advanced Drug Delivery …, 2023 - Elsevier
DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug
delivery systems. These nanostructures can be functionalized with guests ranging from …

Self-assembly of DNA nanostructure containing cell-specific aptamer as a precise drug delivery system for cancer therapy in non-small cell lung cancer

N Wang, C Yu, T Xu, D Yao, L Zhu, Z Shen… - Journal of …, 2022 - Springer
Background As the most common subtype in lung cancer, the precise and efficient treatment
for non-small cell lung cancer (NSCLC) remains an outstanding challenge owing to early …

Pure DNA scaffolded drug delivery systems for cancer therapy

H Aliouat, Y Peng, Z Waseem, S Wang, W Zhou - Biomaterials, 2022 - Elsevier
The development of effective drug delivery system is highly important for targeted tumor
therapy. Over the past few decades, a number of biomaterials have been extensively …

Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy

K Jiang, D Zhao, R Ye, X Liu, C Gao, Y Guo, C Zhang… - Nanoscale, 2022 - pubs.rsc.org
Spherical nucleic acid (SNA), as a good gene delivery system, has a good application
prospect for transdermal administration in skin disorder treatment. However, most of the …

Engineering CpG‐ASO‐Pt‐Loaded Macrophages (CAP@ M) for Synergistic Chemo‐/Gene‐/Immuno‐Therapy

Y Wang, L Zhang, Y Liu, L Tang, J He… - Advanced …, 2022 - Wiley Online Library
Adoptive cell therapy by natural cells for drug delivery has achieved encouraging progress
in cancer treatment over small‐molecule drugs. Macrophages have a great potential in …