Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on
human health ranging from fatigue and numbness to organ failure and death in extreme …

Protein misfolding and aggregation are associated with more than twenty diseases, such as
neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may …

Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

Protein misfolding and aggregation can be induced by a wide variety of factors, such as
dominant disease-associated mutations, changes in the environmental conditions (pH …

Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …

Covering: up to February 2015 Over the past twenty-five years, isothermal titration
calorimetry (ITC) has become a potent tool for the study a great variety of molecular …

Insulin is a therapeutically relevant molecule with use in treating diabetes patients.
Unfortunately, it undergoes a range of untoward and often unpredictable physical …

Protein aggregation and amyloid fibrillation are responsible for several serious pathological
conditions (like type II diabetes, Alzheimer's and Parkinson's diseases etc.) and protein …

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …