TFOS DEWS II tear film report

MDP Willcox, P Argüeso, GA Georgiev, JM Holopainen… - The ocular …, 2017 - Elsevier
The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

Non-invasive biomarkers for early detection of breast cancer

J Li, X Guan, Z Fan, LM Ching, Y Li, X Wang, WM Cao… - Cancers, 2020 - mdpi.com
Simple Summary Early diagnosis of breast cancer greatly increases the chance of cure and
survival from the disease. The mammogram is widely used for early detection of breast …

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021 - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

BCLA CLEAR–Contact lens technologies of the future

L Jones, A Hui, CM Phan, ML Read, D Azar… - Contact lens and …, 2021 - Elsevier
Contact lenses in the future will likely have functions other than correction of refractive error.
Lenses designed to control the development of myopia are already commercially available …

Tear analysis in ocular surface diseases

L Zhou, RW Beuerman - Progress in retinal and eye research, 2012 - Elsevier
The thin layer of tears covering the ocular surface are a complex body fluid containing
thousands of molecules of varied form and function of several origins. In this review, we …

Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors

GA de Souza, LMF de Godoy, M Mann - Genome biology, 2006 - Springer
Background The tear film is a thin layer of fluid that covers the ocular surface and is involved
in lubrication and protection of the eye. Little is known about the protein composition of tear …

Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics

L Zhou, RW Beuerman, CM Chan… - Journal of proteome …, 2009 - ACS Publications
The proteins found in tears have an important role in the maintenance of the ocular surface
and changes in the quality and quantity of tear components reflect changes in the health of …

Extraction of membrane proteins by differential solubilization for separation using two‐dimensional gel electrophoresis

MP Molloy, BR Herbert, BJ Walsh, MI Tyler… - …, 1998 - Wiley Online Library
We describe the extraction and enrichment of membrane proteins for separation by two‐
dimensional polyacrylamide gel electrophoresis (2‐D PAGE) after differential solubilization …

Tears as a source of biomarkers for ocular and systemic diseases

NT und Hohenstein-Blaul, S Funke, FH Grus - Experimental eye research, 2013 - Elsevier
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers
which are correlated with a certain disease. Tear proteins have been investigated …

Role of lactoferrin in the tear film

JL Flanagan, MDP Willcox - Biochimie, 2009 - Elsevier
The surface of the eye provides an inert barrier against infection. Through its unique
combination of antimicrobial action and anti-inflammatory activities lactoferrin (Lf) in the tear …