Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp
(WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

▪ Abstract The synthesis of ribosomes is one of the major metabolic pathways in all cells. In
addition to around 75 individual ribosomal proteins and 4 ribosomal RNAs, synthesis of a …

We previously identified a complex of 3′→ 5′ exoribonucleases, designated the
exosome, that is expected to play a major role in diverse RNA processing and degradation …

The function of the nucleolus as a factory for assembling ribosomal subunits is well
established, but many unrelated activities have been discovered over the past decade. Our …

We have developed techniques for the detailed analysis of cis‐acting sequences in the pre‐
rRNA of Saccharomyces cerevisiae and used these to study the processing of internal …

Ribosomes are perhaps the most critical macromolecular machine as they are tasked with
carrying out protein synthesis in cells. They are incredibly complex structures composed of …

The synthesis of ribosomes is one of the major cellular activities, and in eukaryotes, it takes
place primarily, although not exclusively, in a specialized subnuclear compartment termed …

A subset of WD40 proteins that contain a DWD motif (for DDB1 binding WD40) is reported to
act as substrate receptors for DDB1-CUL4-ROC1 (for Damaged DNA Binding 1–Cullin 4 …