Most of the cytotoxic anticancer drugs in current use have been shown to induce apoptosis
in susceptible cells. The fact that disparate agents, which interact with different targets …

Folate, a water-soluble B vitamin, has recently garnered much attention because of its
purported role in the pathogenesis of cardiovascular disease, 1–4 neural tube defects, 5–7 …

Cell death induced by cisplatin was studied in Chinese hamster ovary cell lines, one
proficient and the other deficient (100-fold sensitive) in DNA excision repair. Previous …

The promoter of the human dihydrofolate reductase (DHFR) gene contains two consensus
binding sites for the DNA binding protein Sp1. DNAse protection and gel mobility shift …

Microarray technology, which allows one to quantitate the expression of thousands of genes
simultaneously, has begun to have a major impact on many different areas of drug discovery …

The search for novel antitumour drugs has reached a plateau phase. The carcinomas
remain almost as intractable as they did 40 years ago and the need for effective therapy is …

Survival is dependent upon the integrity of DNA. It is essential to pass accurate complete
genetic information to each daughter cell and on to the next generation of the species. Only …

Two ionophores specific for K+, valinomycin and beauvericin, induce a type of cell death
very similar to apoptosis due to tumor necrosis factor (TNFα). Both ionophores cause …

To elucidate the genomics of cellular responses to cancer treatment, we analyzed the
expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and …

Inherited genetic variations can affect a patient's response to chemotherapeutic agents
given for cancer. Pharmacogenetics aims to use knowledge of these variations …