Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

The α/β hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no
obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a …

Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by
cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in …

The alpha beta-hydrolase fold family of enzymes is rapidly becoming one of the largest
group of structurally related enzymes with diverse catalytic functions. Members in this family …

Eicosanoids have been implicated in a vast number of devastating inflammatory conditions,
including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different …

The epoxide hydrolases (EHs) are enzymes present in all living organisms, which transform
epoxide containing lipids by the addition of water. In plants and animals, many of these lipid …

▪ Abstract Organisms are exposed to epoxide-containing compounds from both exogenous
and endogenous sources. In mammals, the hydration of these compounds by various …

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …

Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …

The cation–π interaction is a potent, general noncovalent binding force that is observed in a
wide range of biological contexts. Here, we present an overview of well documented cases …