Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
The physiology and pathophysiology of T-tubules in the heart
In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
The role of junctophilin proteins in cellular function
SE Lehnart, XHT Wehrens - Physiological reviews, 2022 - journals.physiology.org
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
Cardiac microtubules in health and heart disease
MA Caporizzo, CY Chen… - Experimental Biology and …, 2019 - journals.sagepub.com
Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …
working force behind each heartbeat. These highly structured cells are packed with dense …
Genome-wide temporal profiling of transcriptome and open chromatin of early cardiomyocyte differentiation derived from hiPSCs and hESCs
Rationale: Recent advances have improved our ability to generate cardiomyocytes from
human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) …
human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) …
STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM)
forms signaling complexes that regulate the membrane potential and contractility of vascular …
forms signaling complexes that regulate the membrane potential and contractility of vascular …
Analysis of cardiac myocyte maturation using CASAAV, a platform for rapid dissection of cardiac myocyte gene function in vivo
Rationale: Loss-of-function studies in cardiac myocytes (CMs) are currently limited by the
need for appropriate conditional knockout alleles. The factors that regulate CM maturation …
need for appropriate conditional knockout alleles. The factors that regulate CM maturation …
SPEG (striated muscle preferentially expressed protein kinase) is essential for cardiac function by regulating junctional membrane complex activity
AP Quick, Q Wang, LE Philippen… - Circulation …, 2017 - Am Heart Assoc
Rationale: Junctional membrane complexes (JMCs) in myocytes are critical microdomains,
in which excitation–contraction coupling occurs. Structural and functional disruption of JMCs …
in which excitation–contraction coupling occurs. Structural and functional disruption of JMCs …
Isoproterenol promotes rapid ryanodine receptor movement to bridging integrator 1 (bin1)–organized dyads
Y Fu, SA Shaw, R Naami, CL Vuong, WA Basheer… - Circulation, 2016 - Am Heart Assoc
Background—The key pathophysiology of human acquired heart failure is impaired calcium
transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at …
transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at …