Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress
conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) …

Viruses must co-opt the cellular translation machinery to produce progeny virions.
Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation …

Protein synthesis in all cells is carried out by macromolecular machines called ribosomes.
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently
emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

The correct translation of mRNA depends critically on the ability to initiate at the right AUG
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …