The safety requirements for vaccines are extremely high since they are administered to
healthy people. For that reason, vaccine development is time-consuming and very …

Recent advances in process analytical technologies and modelling techniques present
opportunities to improve industrial chromatography control strategies to enhance process …

The realization of an end‐to‐end integrated continuous lab‐scale process for monoclonal
antibody manufacturing is described. For this, a continuous cultivation with filter‐based cell …

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess
(ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to …

Control of column loading in Protein A chromatography is a crucial part of development of
robust and flexible process platforms for continuous production of monoclonal antibody …

A continuous integrated bioprocess available from the earliest stages of process
development allows for an easier, more efficient and faster development and …

An optimization study of an integrated periodic counter-current chromatography (PCC)
process in a monoclonal antibody (mAb) downstream process at lab scale, is presented in …

Buffer management for biopharmaceutical purification processes include buffer preparation,
storage of buffers and restocking the buffers when needed. This is usually performed …

Integrated continuous downstream processes with process analytical technology offer a
promising opportunity to reduce production costs and increase process flexibility and …

The methodology for production of biologics is going through a paradigm shift from batch‐
wise operation to continuous production. Lot of efforts are focused on integration …