Hot-melt extrusion: from theory to application in pharmaceutical formulation
Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …
entities in the developmental pipeline and for improving products already on the market. In …
Melt extrusion with poorly soluble drugs–An integrated review
Over the last few decades, hot melt extrusion (HME) has emerged as a successful
technology for a broad spectrum of applications in the pharmaceutical industry. As indicated …
technology for a broad spectrum of applications in the pharmaceutical industry. As indicated …
Melt extrusion with poorly soluble drugs
Melt extrusion (ME) over recent years has found widespread application as a viable drug
delivery option in the drug development process. ME applications include taste masking …
delivery option in the drug development process. ME applications include taste masking …
Hot melt extrusion: Highlighting physicochemical factors to be investigated while designing and optimizing a hot melt extrusion process
Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing
numerous types of drug delivery systems and dosage forms. It offers several advantages: no …
numerous types of drug delivery systems and dosage forms. It offers several advantages: no …
A review of pharmaceutical extrusion: Critical process parameters and scaling-up
Hot melt extrusion has been a widely used process in the pharmaceutical area for three
decades. In this field, it is important to optimize the formulation in order to meet specific …
decades. In this field, it is important to optimize the formulation in order to meet specific …
Interactions between drugs and polymers influencing hot melt extrusion
Y Li, H Pang, Z Guo, L Lin, Y Dong, G Li… - Journal of Pharmacy …, 2014 - academic.oup.com
Objectives Hot melt extrusion (HME) as a technique for producing amorphous solid
dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge …
dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge …
Physical stability of pharmaceutical formulations: solid-state characterization of amorphous dispersions
Y Guo, E Shalaev, S Smith - TrAC Trends in Analytical Chemistry, 2013 - Elsevier
The acceptable stability of the drug formulations is one of the basic requirements for
pharmaceutical development and commercialization. The increasing application of enabling …
pharmaceutical development and commercialization. The increasing application of enabling …
Innovations in thermal processing: hot-melt extrusion and KinetiSol® dispersing
Thermal processing has gained much interest in the pharmaceutical industry, particularly for
the enhancement of solubility, bioavailability, and dissolution of active pharmaceutical …
the enhancement of solubility, bioavailability, and dissolution of active pharmaceutical …
A review of PAT strategies in secondary solid oral dosage manufacturing of small molecules
S Laske, A Paudel, O Scheibelhofer, S Sacher… - Journal of …, 2017 - Elsevier
Pharmaceutical solid oral dosage product manufacturing is a well-established, yet
revolutionizing area. To this end, process analytical technology (PAT) involves …
revolutionizing area. To this end, process analytical technology (PAT) involves …
Chemically identical but physically different: A comparison of spray drying, hot melt extrusion and cryo-milling for the formulation of high drug loaded amorphous solid …
S Dedroog, C Huygens, G Van den Mooter - European Journal of …, 2019 - Elsevier
In spite of the large research efforts in the past two decades, it is still difficult, if possible at all,
to predict what manufacturing technology will lead to the best amorphous solid dispersions …
to predict what manufacturing technology will lead to the best amorphous solid dispersions …