The NOD, LRR, and pyrin domain-containing 3 (NLRP3) protein has been established as a
central component of the inflammasome and regulates the inflammatory response to a …

Exposure to amorphous silica nanoparticles (SiNPs) has increased dramatically, and
concerns are growing about their potential health effects. However, their long-term systemic …

Objective Diabetic nephropathy (DN) is characterized by glomerular and tubulointerstitial
injury, proteinuria and remodeling. Here we examined whether the combination of an …

Background Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart
failure with preserved ejection fraction, is a predictor of future cardiovascular events. We …

Hyperglycemia-induced production of endothelin (ET)-1 is a hallmark of endothelial
dysfunction in diabetes. Although the detrimental vascular effects of increased ET-1 are well …

Objective Cardiac hypertrophy is an adaptive response to physiological and pathological
stimuli, the latter of which frequently progresses to valvulopathy, heart failure and sudden …

Persistent inflammation promotes development and progression of heart failure (HF).
TWEAK (TNF-Related WEAK Inducer Of Apoptosis), a NF-κB-and/or AP-1-responsive …

An increasing number of genetically modified mouse models has become available in
recent years. Moreover, the number of pharmacological studies performed in mice is high …

Heart failure with preserved ejection fraction (HFpEF) has become a major health issue
because of its high mortality, high heterogeneity, and poor prognosis. Using genomic data to …

Re-establishing blood supply is the primary goal for reducing myocardial injury in subjects
with ischemic heart disease. Paradoxically, reperfusion results in nitroxidative stress and a …