IL-36 cytokines: regulators of inflammatory responses and their emerging role in immunology of reproduction

JM Murrieta-Coxca, S Rodríguez-Martínez… - International journal of …, 2019 - mdpi.com
The IL-36 subfamily of cytokines has been recently described as part of the IL-1 superfamily.
It comprises three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ), their receptor (IL …

IL-36 in chronic inflammation and cancer

MF Neurath - Cytokine & Growth Factor Reviews, 2020 - Elsevier
IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific
cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP …

IL-36 in chronic inflammation and fibrosis—bridging the gap?

M Elias, S Zhao, HT Le, J Wang… - The Journal of …, 2021 - Am Soc Clin Investig
IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor
antagonist (IL-36Ra). The three endogenous agonists, IL-36α,–β, and–γ, act primarily as …

Emerging role of the IL-36/IL-36R Axis in multiple inflammatory skin diseases

F Ahmad, MA Alam, AW Ansari, A Jochebeth… - Journal of Investigative …, 2024 - Elsevier
IL-36 is a most recent member of the IL-1 cytokine family, primarily expressed at barrier sites
of the body such as the skin, lungs, and intestine. It plays a vital role in inflammation and is …

IL-36γ induces a transient HSV-2 resistant environment that protects against genital disease and pathogenesis

JK Gardner, MM Herbst-Kralovetz - Cytokine, 2018 - Elsevier
Abstract Herpes simplex virus 2 (HSV-2) causes a persistent, lifelong infection that increases
risk for sexually transmitted infection acquisition. Both the lack of a vaccine and the need for …

Role of IL-36 cytokines in the regulation of angiogenesis potential of trophoblast cells

JM Murrieta-Coxca, RN Gutiérrez-Samudio… - International journal of …, 2020 - mdpi.com
IL-36 cytokines (the agonists IL-36α, IL-36β, IL-36γ, and the antagonist IL-36Ra) are
expressed in the mouse uterus and associated with maternal immune response during …

Spesolimab, the first‐in‐class anti‐IL‐36R antibody: From bench to clinic

A Morita, Y Okubo, S Imafuku… - The Journal of …, 2024 - Wiley Online Library
Inflammatory diseases that are driven by several pro‐inflammatory cytokines has resulted in
in the development of targeted therapies across different disease settings. Interleukin (IL)‐36 …

Endometrial epithelial ARID1A is required for uterine immune homeostasis during early pregnancy

RM Marquardt, SH Ahn, JJ Reske, RL Chandler… - International Journal of …, 2022 - mdpi.com
A growing body of work suggests epigenetic dysregulation contributes to endometriosis
pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich …

[PDF][PDF] IL-36 及其与疾病相关性的研究进展

程梦琳, 包永芬, 白育庭, 单士刚 - 现代免疫学, 2018 - shmy.shsmu.edu.cn
白细胞介素36 (interleukin 36, IL-36) 是IL-1 家族新成员, 由3 个生物学功能相似的成员IL-36α,
IL-36β 和IL-36γ 组成. IL-36 成员的共同受体为IL-36R, 可与IL-1 受体辅助蛋白(IL-36RAcP) …

[图书][B] The Role of ARID1A in Endometriosis-Related Infertility

RM Marquardt - 2022 - search.proquest.com
The inner lining of the uterus, the endometrium, is composed of a luminal epithelial cell layer
supported by an underlying stroma which contains epithelial gland structures. These distinct …