IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP …
M Elias, S Zhao, HT Le, J Wang… - The Journal of …, 2021 - Am Soc Clin Investig
IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor antagonist (IL-36Ra). The three endogenous agonists, IL-36α,–β, and–γ, act primarily as …
F Ahmad, MA Alam, AW Ansari, A Jochebeth… - Journal of Investigative …, 2024 - Elsevier
IL-36 is a most recent member of the IL-1 cytokine family, primarily expressed at barrier sites of the body such as the skin, lungs, and intestine. It plays a vital role in inflammation and is …
JK Gardner, MM Herbst-Kralovetz - Cytokine, 2018 - Elsevier
Abstract Herpes simplex virus 2 (HSV-2) causes a persistent, lifelong infection that increases risk for sexually transmitted infection acquisition. Both the lack of a vaccine and the need for …
JM Murrieta-Coxca, RN Gutiérrez-Samudio… - International journal of …, 2020 - mdpi.com
IL-36 cytokines (the agonists IL-36α, IL-36β, IL-36γ, and the antagonist IL-36Ra) are expressed in the mouse uterus and associated with maternal immune response during …
A Morita, Y Okubo, S Imafuku… - The Journal of …, 2024 - Wiley Online Library
Inflammatory diseases that are driven by several pro‐inflammatory cytokines has resulted in in the development of targeted therapies across different disease settings. Interleukin (IL)‐36 …
RM Marquardt, SH Ahn, JJ Reske, RL Chandler… - International Journal of …, 2022 - mdpi.com
A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich …
The inner lining of the uterus, the endometrium, is composed of a luminal epithelial cell layer supported by an underlying stroma which contains epithelial gland structures. These distinct …