Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Metal-organic framework (MOF) is an exciting class of porous biomaterials that have been
considered as a carrier to store and deliver therapeutic drugs. However, similar to other …

Cancer diagnosis and therapeutics (theranostics) based on the tumor microenvironment
(TME) and biomarkers has been an emerging approach for precision medicine. DNA …

Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …

Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …

Potassium (K+) channels are highly regulated membrane proteins that control the potassium
ion flux and respond to different cellular stimuli. These ion channels are grouped into three …