Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Targeted protein degradation refers to the use of small molecules to induce the selective
degradation of proteins. In its most common form, this degradation is achieved through …

Cell proliferation and cell growth are two tightly linked processes, as the proliferation
program cannot be executed without proper accumulation of cell mass, otherwise …

Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

Recent studies have greatly illuminated the genomic landscape of the myelodysplastic
syndromes (MDS), and the pace of discovery is accelerating. The most common mutations …

Ribosomal biogenesis is tightly associated with cellular activities, such as growth,
proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate …

The protein cereblon (CRBN) is a substrate receptor of the cullin 4-really interesting new
gene (RING) E3 ubiquitin ligase complex CRL4 CRBN. Targeting CRBN mediates selective …

Ribosomopathies are diseases caused by alterations in the structure or function of
ribosomal components. Progress in our understanding of the role of the ribosome in …

Highlights•IMID's molecular mechanism explain their efficacy in hematological
malignancies.•Lenalidomide-treated patients become resistant through cancer-specific …

Thalidomide and its analogues (lenalidomide and pomalidomide) are small molecule
glutamic acid derivatives of the immunomodulatory drug (IMiD) class. In addition to the …