We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical
exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms …

Background Multiple sclerosis (MS) is an immune‐mediated disease of the central nervous
system affecting an estimated 1.3 million people worldwide. It is characterised by a variety of …

Background A moderate to high level of physical activity, including regular exercise,
represents an established behavioral and rehabilitative approach for persons with multiple …

Objective To understand the benefits and harms of physical activity in people who may
require a wheelchair with a focus on people with multiple sclerosis (MS), cerebral palsy …

Background Fatigue contributes a significant burden of disease for people with multiple
sclerosis (PwMS). Modifiable lifestyle factors have been recognized as having a role in a …

Background Lifestyle self-management as an intervention for people living with multiple
sclerosis (plwMS) is an emerging area of research. Previous reviews have highlighted a …

Background: Fatigue is a common, debilitating symptom of multiple sclerosis (MS) without a
current standardised treatment. Objective: The aim of this systematic review with network …

Background: A review of the safety profile of exercise training in multiple sclerosis (MS) has
not been conducted since 2013. Objective: We undertook a systematic review and meta …

Objective To assess the benefits of neurological rehabilitation and the dose-response
relationship for the treatment of mobility and balance in multiple sclerosis. Methods We …

Background Suppressors of cytokine signaling (SOCS) and brain-derived neurotrophic
factor (BDNF) are important immunologic, and neurotrophic factors for MS pathogenesis …