Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is
responsible for many biological processes. Fucose conjugation via α (1, 2), α (1, 3), α (1, 4) …

Glycosylation changes are key molecular events in tumorigenesis, progression and
glycosyltransferases play a vital role in the this process. FUT8 belongs to the …

Liver cancer is the fifth most common cancer, but the second leading cause of cancer death,
in the world, with more than 700,000 fatalities annually. The major etiology of liver cancer is …

Several mechanisms have been proposed to explain the E-cadherin dysfunction in cancer,
including genetic and epigenetic alterations. Nevertheless, a significant number of human …

FUT8 is an essential α-1, 6-fucosyltransferase that fucosylates the innermost GlcNAc of N-
glycans, a process called core fucosylation. In vitro, FUT8 exhibits substrate preference for …

Lung cancer is a disease that influences human health and has become a leading cause of
cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage. It is …

Cancer-associated fibroblasts (CAFs) are the main cancer-promoting component in the
tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). α1, 6 …

Cell surface carbohydrates, termed “glycans,” are ubiquitous posttranslational effectors that
can tune cancer progression. Often aberrantly displayed or found at atypical levels on …

Core fucosylation, the attachment of α1, 6‐fucose to the innermost N‐acetylglucosamine
(GlcNAc) residue of N‐glycans, has a strong relationship with tumor growth, invasion …