Breast cancer is the most common cancer and the deadliest among women worldwide.
Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen …

The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

The immune system functions in a sexually dimorphic manner, with females exhibiting more
robust immune responses than males. However, how female sex hormones affect immune …

Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Gene expression profiling has reshaped our understanding of breast cancer by defining and
characterizing four main intrinsic molecular subtypes: human epidermal growth factor …

To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with
somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

The interaction of regulatory proteins with the complex nucleoprotein structures that are
found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms …

Sex-based differences in human disease are caused in part by the levels of endogenous
sex steroid hormones which regulate mitochondrial metabolism. This review updates a …