[HTML][HTML] Oxytocin in general anxiety and social fear: a translational approach

ID Neumann, DA Slattery - Biological psychiatry, 2016 - Elsevier
The neuropeptide oxytocin (OXT) has been revealed as a profound anxiolytic and antistress
factor of the brain, besides its many prosocial and reproductive effects. Therefore, there is …

[HTML][HTML] Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

K Uvnäs-Moberg, L Handlin - Frontiers in psychology, 2015 - frontiersin.org
Oxytocin, a hypothalamic nonapeptide, is linked to increased levels of social interaction, well-
being and anti-stress effects. The effects of oxytocin that is released by sensory stimulation …

[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Germline Chd8 haploinsufficiency alters brain development in mouse

AL Gompers, L Su-Feher, J Ellegood, NA Copping… - Nature …, 2017 - nature.com
The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …

The roots of empathy: Through the lens of rodent models

KZ Meyza, IBA Bartal, MH Monfils, JB Panksepp… - Neuroscience & …, 2017 - Elsevier
Empathy is a phenomenon often considered dependent on higher-order emotional control
and an ability to relate to the emotional state of others. It is, by many, attributed only to …

[图书][B] Translational mouse models of autism: advancing toward pharmacological therapeutics

TM Kazdoba, PT Leach, M Yang, JL Silverman… - 2016 - Springer
Animal models provide preclinical tools to investigate the causal role of genetic mutations
and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and …

The oxytocin–vasopressin pathway in the context of love and fear

CS Carter - Frontiers in endocrinology, 2017 - frontiersin.org
Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their
receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an …

Metabolic effects of oxytocin

SE McCormack, JE Blevins, EA Lawson - Endocrine reviews, 2020 - academic.oup.com
There is growing evidence that oxytocin (OXT), a hypothalamic hormone well recognized for
its effects in inducing parturition and lactation, has important metabolic effects in both sexes …

The BTBR mouse model of idiopathic autism–current view on mechanisms

KZ Meyza, DC Blanchard - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental
disorder, with current estimates of more than 1% of affected children across nations. The …

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

JE Blevins, DG Baskin - Physiology & behavior, 2015 - Elsevier
The fact that more than 78 million adults in the US are considered overweight or obese
highlights the need to develop new, effective strategies to treat obesity and its associated …