The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

The spider genus Latrodectus includes the widely known black widows, notorious because
of the extreme potency of their neurotoxic venom. The genus has a worldwide distribution …

Activity-dependent regulation of dendritic protein synthesis is critical for enduring changes in
synaptic function, but how the unique features of distinct activity patterns are decoded by the …

Action potential-independent transmitter release is random and produces small
depolarizations in the postsynaptic neuron. This process is, therefore, not thought to play a …

We examined dendritic protein synthesis after a prolonged blockade of action potentials
alone and after a blockade of both action potentials and miniature excitatory synaptic events …

The mechanisms that induce Alzheimer's disease (AD) are largely unknown thereby
deterring the development of disease-modifying therapies. One working hypothesis of AD is …

Alzheimer disease is a progressive neurodegenerative brain disorder that leads to major
debilitating cognitive deficits. It is believed that the alterations capable of causing brain …

Considerable evidence suggests that the synapse is the most sensitive CNS element for
ethanol effects. Although most alcohol research has focussed on the postsynaptic sites of …

The black widow spider venom contains several large protein toxins—latrotoxins—that are
selectively targeted against different classes of animals: vertebrates, insects, and …