Since the discovery of interferons (IFNs), considerable progress has been made in
describing the nature of the cytokines themselves, the signalling components that direct the …

Many viruses infect humans and most are controlled satisfactorily by the immune system
with limited damage to host tissues. Some viruses, however, do cause overt damage to the …

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of
infected persons; approximately 50% of these do not respond to therapy. We performed a …

Comparisons of DNA from archaic and modern humans show that these groups interbred,
and in some cases received an evolutionary advantage from doing so. This process …

The 2′-5′ oligoadenylate synthetases (OAS) are interferon-induced antiviral enzymes that
recognize virally produced dsRNA and initiate RNA destabilization through activation of …

Background & Aims: Pegylated interferon (IFN)-α plus ribavirin is the most effective treatment
of chronic hepatitis C but has unpleasant side effects and high costs. A large proportion of …

Hantaan virus (HTNV), a Hantavirus serotype that is prevalent in Asia, causes hemorrhagic
fever with renal syndrome (HFRS) with high mortality in human race. However, the …

The study of antiviral pathways to reveal methods for the effective response and clearance of
virus is closely related to understanding interferon (IFN) signaling and its downstream target …

Background The number of genome-wide association studies (GWAS) is growing rapidly
leading to the discovery and replication of many new disease loci. Combining results from …

The SARS-CoV-2 pandemic has become one of the most serious health concerns globally.
Although multiple vaccines have recently been approved for the prevention of coronavirus …