Current status and prospects of clinical treatment of osteosarcoma
ZY Jiang, JB Liu, XF Wang, YS Ma… - Technology in cancer …, 2022 - journals.sagepub.com
Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …
The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications
The discovery of the benefits of castration for prostate cancer treatment in 1941 led to
androgen deprivation therapy, which remains a mainstay of the treatment of men with …
androgen deprivation therapy, which remains a mainstay of the treatment of men with …
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate
The androgen receptor (AR) is central in prostate tissue identity and differentiation, and
controls normal growth-suppressive, prostate-specific gene expression. It also drives …
controls normal growth-suppressive, prostate-specific gene expression. It also drives …
Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2
Elevated androgen receptor (AR) expression is a hallmark of castration-resistant prostate
cancer (CRPC) and contributes to the restoration of AR signaling under the conditions of …
cancer (CRPC) and contributes to the restoration of AR signaling under the conditions of …
CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer
YC Wen, VTN Tram, WH Chen, CH Li, HL Yeh… - Cell death & …, 2023 - nature.com
Current treatment options for prostate cancer focus on targeting androgen receptor (AR)
signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage …
signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage …
[HTML][HTML] Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs
One critical mechanism through which prostate cancer (PCa) adapts to treatments targeting
androgen receptor (AR) signaling is the emergence of ligand-binding domain-truncated and …
androgen receptor (AR) signaling is the emergence of ligand-binding domain-truncated and …
Targeting CBX3 with a dual BET/PLK1 inhibitor enhances the antitumor efficacy of CDK4/6 inhibitors in prostate cancer
H Liang, C Yang, R Zeng, Y Song, J Wang… - Advanced …, 2023 - Wiley Online Library
The development of castration‐resistant prostate cancer (CRPC) is a significant factor that
reduces life expectancy among patients with prostate cancer. Previously, it is reported that …
reduces life expectancy among patients with prostate cancer. Previously, it is reported that …
Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM …
MD Nyquist, IM Coleman, JM Lucas, D Li, B Hanratty… - Cancer Research, 2023 - AACR
The androgen receptor (AR) pathway regulates key cell survival programs in prostate
epithelium. The AR represents a near-universal driver and therapeutic vulnerability in …
epithelium. The AR represents a near-universal driver and therapeutic vulnerability in …
LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer
The lysine demethylase LSD1 (also called KDM1A) plays important roles in promoting
multiple malignancies including both hematologic cancers and solid tumors. LSD1 targets …
multiple malignancies including both hematologic cancers and solid tumors. LSD1 targets …
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer
D Ren, W Li, R Zeng, X Liu, H Liang, W Xiong… - Cell Death & …, 2024 - nature.com
RB transcriptional corepressor 1 (RB) deletion is the most important genomic factor
associated with the prognosis of castration-resistant prostate cancer (CRPC) patients …
associated with the prognosis of castration-resistant prostate cancer (CRPC) patients …