Exosome-mediated metastasis: communication from a distance

I Wortzel, S Dror, CM Kenific, D Lyden - Developmental cell, 2019 - cell.com
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating
cancer and a major cause of cancer mortality. Cell-cell communication via extracellular …

Extracellular vesicles in cancer—implications for future improvements in cancer care

R Xu, A Rai, M Chen, W Suwakulsiri… - Nature reviews Clinical …, 2018 - nature.com
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Extracellular vesicles: new classification and tumor immunosuppression

M Sheta, EA Taha, Y Lu, T Eguchi - Biology, 2023 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …

Podoplanin in inflammation and cancer

M Quintanilla, L Montero-Montero, J Renart… - International journal of …, 2019 - mdpi.com
Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

MSC-exosome: a novel cell-free therapy for cutaneous regeneration

P Wu, B Zhang, H Shi, H Qian, W Xu - Cytotherapy, 2018 - Elsevier
Cutaneous regeneration is a dynamic and complex process that requires a series of
coordinated interactions involving epidermal cells, dermal cells, growth factors, the …

Fat therapeutics: the clinical capacity of adipose-derived stem cells and exosomes for human disease and tissue regeneration

L Shukla, Y Yuan, R Shayan, DW Greening… - Frontiers in …, 2020 - frontiersin.org
Fat grafting is a well-established surgical technique used in plastic surgery to restore
deficient tissue, and more recently, for its putative regenerative properties. Despite more …

To protect and to preserve: novel preservation strategies for extracellular vesicles

GD Kusuma, M Barabadi, JL Tan… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by
stem cells exert similar therapeutic effects and these have been proposed as an alternative …

Extracellular vesicles in human reproduction in health and disease

C Simon, DW Greening, D Bolumar… - Endocrine …, 2018 - academic.oup.com
Extensive evidence suggests that the release of membrane-enclosed compartments, more
commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of …

Understanding extracellular vesicle diversity–current status

DW Greening, RJ Simpson - Expert review of proteomics, 2018 - Taylor & Francis
ABSTRACT Introduction: Extracellular vesicles (EVs) represent an important mode of
intercellular communication. There is now a growing awareness that predominant EV …

The emerging roles of tumor-derived exosomes in hematological malignancies

M Boyiadzis, TL Whiteside - Leukemia, 2017 - nature.com
Abstract Exosomes are small (30–150 nm) membranous vesicles of endocytic origin
produced by all cells under physiological and pathological conditions. They have recently …