Over the past decade, the number of publications using micro-computed tomography (μCT)
imaging in preclinical in vivo studies has risen exponentially. Higher spatial and temporal …

Computed tomography (CT) is one of the most valuable modalities for in vivo imaging
because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily …

Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and
cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic …

Cryptotanshinone (CTS), a lipophilic compound extracted from root of Salvia miltiorrhiza
(Danshen), has demonstrated multiple pharmacological activities, including anti …

Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent
US Food and Drug Administration approval of covalent inhibitors of KRAS G12C such as …

Although increasing used in the preclinical testing of new anti-fibrotic drugs, a thorough
validation of micro-computed tomography (CT) in pulmonary fibrosis models has not been …

Transforming growth factor β activation by the αvβ6 integrin is central to the pathogenesis of
idiopathic pulmonary fibrosis. Expression of the αvβ6 integrin is increased in fibrotic lung …

As drug development shifts over time to address unmet medical needs and more targeted
therapies are developed, previously unseen pharmacological or off-target effects may occur …

Objective. To define the sensitivity of microcomputed tomography‐(micro‐CT‐) derived
descriptors for the quantification of lung damage caused by elastase instillation. Materials …

Several non-invasive imaging techniques are used to investigate the effect of pathologies
and treatments over time in mouse models. Each preclinical in vivo technique provides …