Urine drug testing is frequently used in clinical, employment, educational, and legal settings
and misinterpretation of test results can result in significant adverse consequences for the …

In Australia and New Zealand, in parallel with other developed countries, the number of
patients prescribed opioids on a long-term basis has grown rapidly over the last decade …

Methadone is used for the treatment of opioid addiction and for treatment of chronic pain.
The safety of methadone has been called into question by data indicating a large increase in …

Description: An independent panel developed cardiac safety recommendations for
physicians prescribing methadone. Methods: Expert panel members reviewed and …

BACKGROUND: Methadone is a potent opioid exerting an analgesic effect through N-methyl-
d-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake …

A force strong enough to inflict damage to neuronal flow and intracranial pressure (ICP). In
the pretissue must penetrate through skin, fat, muscle, bone, dura, and cerebrospinal fluid …

Methadone is highly effective in treating opioid dependence, and it is also used as an
analgesic for second-line management of chronic pain. However, recent increases in …

Overdose education and naloxone distribution (OEND) is an intervention that addresses
overdose, but has not been studied among people who take methadone, a drug involved in …

The number of deaths associated with methadone use increased dramatically in parallel
with marked increases in its use, particularly for treatment of chronic pain. To develop a …

Background Pain occurs in 50% of patients with cancer at the time of diagnosis, and nearly
80% of patients with advanced stage cancer have moderate to severe pain. Assessment of …