Advances and applications in the quest for orthologs
Gene families evolve by the processes of speciation (creating orthologs), gene duplication
(paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and …
(paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and …
OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more
OMA is an established resource to elucidate evolutionary relationships among genes from
currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise …
currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise …
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field
SSV Vasquez, J van Dam… - Molecular Biology of the …, 2021 - Am Soc Cell Biol
Cilia are microtubule-based organelles with important functions in motility and sensation.
They contribute to a broad spectrum of developmental disorders called ciliopathies and …
They contribute to a broad spectrum of developmental disorders called ciliopathies and …
Genomes of early-diverging streptophyte algae shed light on plant terrestrialization
Mounting evidence suggests that terrestrialization of plants started in streptophyte green
algae, favoured by their dual existence in freshwater and subaerial/terrestrial environments …
algae, favoured by their dual existence in freshwater and subaerial/terrestrial environments …
The genome of Prasinoderma coloniale unveils the existence of a third phylum within green plants
Genome analysis of the pico-eukaryotic marine green alga Prasinoderma coloniale CCMP
1413 unveils the existence of a novel phylum within green plants (Viridiplantae), the …
1413 unveils the existence of a novel phylum within green plants (Viridiplantae), the …
Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections
The protozoan parasite Leishmania possesses a single flagellum, which is remodelled
during the parasite's life cycle from a long motile flagellum in promastigote forms in the sand …
during the parasite's life cycle from a long motile flagellum in promastigote forms in the sand …
Protein function prediction as approximate semantic entailment
M Kulmanov, FJ Guzmán-Vega… - Nature Machine …, 2024 - nature.com
Abstract The Gene Ontology (GO) is a formal, axiomatic theory with over 100,000 axioms
that describe the molecular functions, biological processes and cellular locations of proteins …
that describe the molecular functions, biological processes and cellular locations of proteins …
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
J Dobbelaere, TY Su, B Erdi, A Schleiffer… - The EMBO …, 2023 - embopress.org
Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …
Ten years of collaborative progress in the quest for orthologs
Accurate determination of the evolutionary relationships between genes is a foundational
challenge in biology. Homology—evolutionary relatedness—is in many cases readily …
challenge in biology. Homology—evolutionary relatedness—is in many cases readily …
Identification of hidden associations among eukaryotic genes through statistical analysis of coevolutionary transitions
Coevolution at the gene level, as reflected by correlated events of gene loss or gain, can be
revealed by phylogenetic profile analysis. The optimal method and metric for comparing …
revealed by phylogenetic profile analysis. The optimal method and metric for comparing …