From multi-omics approaches to precision medicine in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …
caused by the degeneration of upper and lower motor neurons for which there is no truly …
Multiomics technologies: role in disease biomarker discoveries and therapeutics
Medical research has been revolutionized after the publication of the full human genome.
This was the major landmark that paved the way for understanding the biological functions …
This was the major landmark that paved the way for understanding the biological functions …
Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data
H Marriott, R Kabiljo, GP Hunt, AA Khleifat… - Acta neuropathologica …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic
heterogeneity. Machine learning approaches have previously been utilised for patient …
heterogeneity. Machine learning approaches have previously been utilised for patient …
Omics data and their integrative analysis to support stratified medicine in neurodegenerative diseases
Molecular and clinical heterogeneity is increasingly recognized as a common characteristic
of neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease …
of neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease …
Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS
Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease.
Increasing the chances of success for future clinical strategies requires more in-depth …
Increasing the chances of success for future clinical strategies requires more in-depth …
Histaminergic transmission slows progression of amyotrophic lateral sclerosis
S Apolloni, S Amadio, P Fabbrizio… - Journal of cachexia …, 2019 - Wiley Online Library
Background Histamine is an immune modulator, neuroprotective, and remyelinating agent,
beneficially acting on skeletal muscles and promoting anti‐inflammatory features in …
beneficially acting on skeletal muscles and promoting anti‐inflammatory features in …
Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by
the loss of upper and lower motor neurons. ALS exhibits high phenotypic variability …
the loss of upper and lower motor neurons. ALS exhibits high phenotypic variability …
Differential vulnerability of oculomotor versus hypoglossal nucleus during ALS: involvement of PACAP
Amyotrophic lateral sclerosis (ALS) is a progressive multifactorial disease characterized by
the loss of motor neurons (MNs). Not all MNs undergo degeneration: neurons of the …
the loss of motor neurons (MNs). Not all MNs undergo degeneration: neurons of the …
[HTML][HTML] Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS
I Dervishi, O Gozutok, K Murnan, M Gautam, D Heller… - Scientific reports, 2018 - nature.com
Developing effective treatment strategies for neurodegenerative diseases require an
understanding of the underlying cellular pathways that lead to neuronal vulnerability and …
understanding of the underlying cellular pathways that lead to neuronal vulnerability and …
Splicing players are differently expressed in sporadic amyotrophic lateral sclerosis molecular clusters and brain regions
Splicing is a tightly orchestrated process by which the brain produces protein diversity over
time and space. While this process specializes and diversifies neurons, its deregulation may …
time and space. While this process specializes and diversifies neurons, its deregulation may …